UGM 2007 Uji Toksikologi Akut

Aim

To determine the potential for acute toxicity which is expressed as the mid-lethal dose range (LD-50), the mode of death during pre-clinical testing, and to understand the spectrum of toxic effects (if any).

Research Team

Protector: Dean of the Faculty of Pharmacy UGM, Yogyakarta, Dr. Marchaban, DESS, Apt

Person responsible: Head of Pharmacology & Toxicology Laboratory, Faculty of Pharmacy UGM,

Yogyakarta, Prof., Lukman Hakim, MSc, PhD, Apt

Member: Dr. Nurlaila, MSi, Apt, Purwantining, MSi, Apt

Test result

1. Up to the 15th day after administration of NUTRIGOLD D capsule suspension orally, from the lowest dose to the highest (312 – 6250.23 mg/kg BW), No death was recorded (% response = 0).
2. Physical observation of toxic symptoms during the first 3 hours until day 15, administration of NUTRIGOLD D with the lowest dose to the highest dose (6250.23 mg/kg BW in female mice did not show toxic effects, both the central nervous system and somatomotor, autonomic nervous , respiratory, cardiovascular, genitourinary gastrointestinal tract, mucous membranes and eyes.
3. The results of macroscopic gross examination of pathology up to the highest dose of 6250.23 mg/kg BW on the vital organs of NUTRIGOLD D administration did not show significant deviations (compared to controls).