{"id":364,"date":"2023-01-20T04:59:48","date_gmt":"2023-01-20T04:59:48","guid":{"rendered":"http:\/\/daunteratai.localhost\/?post_type=research&p=364"},"modified":"2023-03-10T11:48:15","modified_gmt":"2023-03-10T11:48:15","slug":"ugm-2012-acute-toxicology-testing-for-nd-60","status":"publish","type":"research","link":"https:\/\/daunteratai.com\/en\/research\/ugm-2012-acute-toxicology-testing-for-nd-60\/","title":{"rendered":"UGM 2007 Uji Toksikologi Akut"},"content":{"rendered":"

Aim<\/h3>\n

To determine the potential for acute toxicity which is expressed as the mid-lethal dose range (LD-50), the mode of death during pre-clinical testing, and to understand the spectrum of toxic effects (if any).<\/p>\n

\n

Research Team<\/h3>\n

Protector: Dean of the Faculty of Pharmacy UGM, Yogyakarta, Dr. Marchaban, DESS, Apt<\/p>\n

Person responsible: Head of Pharmacology & Toxicology Laboratory, Faculty of Pharmacy UGM,<\/p>\n

Yogyakarta, Prof., Lukman Hakim, MSc, PhD, Apt<\/p>\n

Member: Dr. Nurlaila, MSi, Apt, Purwantining, MSi, Apt<\/p>\n

\n

Test result<\/h3>\n
    \n
  1. Up to the 15th day after administration of NUTRIGOLD D capsule suspension orally, from the lowest dose to the highest (312 \u2013 6250.23 mg\/kg BW), No death was recorded (% response = 0).<\/li>\n
  2. Physical observation of toxic symptoms during the first 3 hours until day 15, administration of NUTRIGOLD D with the lowest dose to the highest dose (6250.23 mg\/kg BW in female mice did not show toxic effects, both the central nervous system and somatomotor, autonomic nervous , respiratory, cardiovascular, genitourinary gastrointestinal tract, mucous membranes and eyes.<\/li>\n
  3. The results of macroscopic gross examination of pathology up to the highest dose of 6250.23 mg\/kg BW on the vital organs of NUTRIGOLD D administration did not show significant deviations (compared to controls).<\/li>\n<\/ol>\n
    \n
    <\/p>\n

    Conclusion<\/h3>\n

    Acute toxicity potential \u2013 oral NUTRIGOLD D in female mice is included in the \u201crelatively\nharmless\u201d category.<\/p>\n

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